Ladislav Š o l t é s - Curriculum Vitae

 

* PROJECTS *

 

 

Effects of natural and synthetic substances on oxidative damage of biomacromolecules. Pro- and antioxidative mechanisms. VEGA No.: 2/0019/19 principal investigator Valachova K.

 

In vitro study of antioxidative/antiinflammatory effects of natural and synthetic compounds. In vivo assessment of medicinal effects of selected compounds in experiments of healing skin wounds. VEGA No.: 2/0008/23 principal investigator Valachova K.

 

 

* PUBLICATION   LIST   (Years  20192023) *

 

Publications in PDF (1997–present)

 

PowerPoint presentations

 

2023

Valachova K., Svik K., Jurcik R., Ondruska L., Biro C., Soltes: Enhanced healing of skin wounds in ischemic rabbits using chitosan/hyaluronan/edaravone composite membranes: effects of laponite, carbon and silver-plated carbon nanofiber fillers. Chemical Papers 77(2023)1835–1841 https://doi.org/10.1007/s11696-022-02553-x

 

Liskova S., Cacanyiova S., Cebova M., Berenyiova A., Kluknavsky M., Valachova K., Soltes L., Bernatova I. ACE-2 inhibition enhances contraction of femoral arteries by stimulating the production of prostaglandin E2: the benefit of taxifolin treatment. Antioxidants, submitted

 

Novak I., Opelika A., Chodak I., Sedliacik J., Kleinova A., Micusik M., Matyasovsky J., Jurkovic P., Valachova K., Soltes L. Cold plasma: An efficient tool for nanotechnological modification of polyester-based polymers. In: "Tailored Functional Materials for Clean and Sustainable Development" T. Tatrishvili, N. K. Rawat, A. R. Abraham, A. K. Haghi (eds.), Apple Academic Press, Palm Bay, FL, USA (2023) pp. X-Y ISBN: 9781774913659 Product Info

 

Novak I., Popelka A., Asanidezhad A., Lehocky M., Chodak I., Sedliacik J., Matyasovsky J., Jurkovic P., Valachova K., Soltes L. Investigation of selected antibacterially modified micro/nano polymers using cold plasma. In: "Nanotechnology-Enhanced Solid Materials Design, Synthesis, Properties, Applications, and Perspectives" L. Pogliani, A. R. Abraham, A. K. Haghi, P. Ranjan (eds), Apple Academic Press, Palm Bay, FL, USA (2023) pp. 237-257 ISBN: 9781774912201 Product Info

 

2022

Valachova K., El Meligy M.A., Soltes L. Hyaluronic acid and chitosan-based electrospun wound dressings: problems and solutions. International Journal of Biological Macromolecules 206(2022)74-91

 

Valent I., Bednarova L., Schreiber I., Bujdak J., Valachova K., Soltes L. Reaction of N-acetylcysteine with Cu2+: Appearance of intermediates with high free radical scavenging activity: Implications for anti-/pro-oxidant properties of thiols. International Journal of Molecular Sciences 23(2022)6199 https://doi.org/10.3390/ijms23116199

 

El Meligy M.A., Valachova K., Juranek I., Tamer M.T., Soltes L. Preparation and physicochemical characterization of gelatin-aldehyde derivatives. Molecules 27(2022)7003

 

Valachova K., Svík K., Biro C., Mach M., Juranek I., Soltes L. Self-associating chitosan-hyaluronan carrier for a drug treating injured skin. In: "Advances in Health and Disease", chapter 5, volume 50,  Lowell T. Duncan (ed.), Nova Science Publishers, Inc., USA (2022), pp. 91-114, ISBN: 978-1-68507-564-4

 

Valachova K., Soltes L. Investigation of the substance antioxidative profile by hyaluronan, Cu(II) and ascorbate. In: "Advances in Health and Diseases", chapter 2, volume 51,  Lowell T. Duncan (ed.), Nova Science Publishers, Inc. (2022), pp. 61-98, ISBN978-1-68507-657-3

 

2021

Valachova K., Svík K., Biro Cs., Collins M. N., Jurcik R., Ondruska L., Soltes L. Impact of ergothioneine, hercynine and histidine on oxidative degradation of hyaluronan and wound healing. Polymers 13(2021)95-103

 

Valachova K., Soltes L. Versatile use of chitosan and hyaluronan in medicine. Molecules 26(2021)1195

 

Valachova K., Soltes L. Self-associating polymers chitosan and hyaluronan for constructing composite membranes as skin-wound dressings carrying therapeutics. Molecules 26(2021)2535

 

Hassan M. A., Tamer M. T., Valachova K., Omer A. M., El-Shafeey M., Mohy Eldin M. S., Soltes L. Antioxidant and antibacterial polyelectrolyte wound dressing based on chitosan/hyaluronan/phosphatidylcholine dihydroquercetin. International Journal of Biological Macromolecules 166(2021)18-31

 

Valachova K., Soltes L. Hyaluronan as a prominent biomolecule with numerous applications in medicine. Int. J. Molecular Sci. 22(2021)7077, https://doi.org/10.3390/ijms22137077

 

Valachova K., Rapta P., Moura N. M  M., Batinic-Haberle I., Soltes L. Ortho isomeric Mn(III) N-alkyl- and alkoxyalkylpyridylporphyrins – enhancers of hyaluronan degradation induced by ascorbate and cupric ions. Int. J. Molecular Sci. 22(2021)8608; https://doi.org/10.3390/ijms22168608

 

Valachova K., Soltes L. Assessment the substance antioxidative profile by hyaluronan, Cu(II) and ascorbate. Pharmaceutics 13(2021)1815

 

Valachova K., Rapta P., Batinic-Haberle I., Soltes L. Manganese porphyrins as pro-oxidants in high-molar-mass hyaluronan oxidative degradation. In: "Green Chemistry and Green Engineering. Processing, Technologies, Properties, and Applications" S. Kulkarni, N. K. Rawat, A. K. Haghi (eds), Apple Academic Press, Palm Bay, FL, USA (2021) pp. 223-241 ISBN: 9781771889001 Product Info

 

Valachova K., Susanikova I., Topolska D., Bogi E., Soltes L. Effects of N-acetylcysteine, glutathione, and glutathione disulfide on NIH 3T3, VH10 and MCF-7 cells exposed to ascorbate and Cu(II) ions. In: "Green Chemistry and Sustainable Technology Biological, Pharmaceutical, and Macromolecular Systems" S. A. Dake, R. S. Shinde, S. C. Ameta, A. K. Haghi (eds), Apple Academic Press, Palm Bay, Florida, USA (2021) pp. 77-93 ISBN: 9781771888622 Product Info

 

Maronek M., Novak I., Michalec I., Matyasovsky J., Jurkovic P., Valachova K., Soltes L. Analysis of fumes arising during fabrication of hybrid adhesive-laser joints. In: "Chemistry and Chemical Engineering for Sustainable Development. Best Practices and Research Directions" M. A. Esteso, A. C. F. Ribeiro, A. K. Haghi (eds), Apple Academic Press, Palm Bay, FL, USA (2021) pp. 229-251 ISBN: 9781771888707 Product Info

 

Valachova K., Rychly J., Janigova I., Csomorova K.,Juranek I., Soltes L. Bucillamine as an efficient H atom donor protects high-molar-mass hyaluronan from oxidative degradation by effective scavenging of free radicals. In: "Current Advances in Chemistry and Biochemistry" Vol. 7, Hooghly, West Bengal, India: B P International, (2021) pp. 123-138 ISBN: 9789391215569

https://stm.bookpi.org/CACB-V7/article/view/1193

 

Book Chapters, electronic re-editions

 

Stankovská, M., Šoltés, L.

Oxidative degradation of hyaluronan: Is melatonin an antioxidant or prooxidant?

(2021) Monomers, Oligomers, Polymers, Composites, and Nanocomposites, pp. 59-67.

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84892270305&partnerID=40&md5=f6acd1d2f9e26d64bec4ab40ff5e7ae3

 

Valachová, K., Mendichi, R., Šoltés, L.

Effect of L-glutathione on high-molar-mass hyaluronan degradation by oxidative system Cu(II) plus ascorbate.

(2021) Monomers, Oligomers, Polymers, Composites, and Nanocomposites, pp. 101-111.

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84857799802&partnerID=40&md5=fefdca35e6de71967a2999065d4d6cea

 

Rapta, P., Valachová, K., Zalibera, M., Šnirc, V., Šoltés, L.

Hyaluronan degradation by reactive oxygen species: Scavenging effect of the hexahydropyridoindole stobadine and two of its derivatives.

(2021) Monomers, Oligomers, Polymers, Composites, and Nanocomposites, pp. 113-126.

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109248213&partnerID=40&md5=bc05f53885664c296b4781d0cfded899

 

Hrabárová, E., Šoltés, L.

Peroxynitrite: A potent endogenous pro-oxidant agent playing an important role in degradation of hyaluronan biopolymer.

(2021) Monomers, Oligomers, Polymers, Composites, and Nanocomposites, pp. 127-138.

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109232722&partnerID=40&md5=e55d7ab8ac1518b554143bcc15024da3

 

Mislovicová, D., Šoltés, L.

Neoglycoproteins of mannan: Preparation, characterization, properties, and applications.

(2021) Monomers, Oligomers, Polymers, Composites, and Nanocomposites, pp. 151-165.

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109234693&partnerID=40&md5=d33671817ac2653aa53a740b3c3441be

 

Šoltés, L.

Hyaluronan - a high-molar-mass messenger reporting on the status of synovial joints: Part II. Pathophysiological status.

(2021) New Steps in Chemical and Biochemical Physics. Pure and Applied Science, pp. 137-152.

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111324320&partnerID=40&md5=33a91ff87151e14a49c4f8fab1a7c8ba

 

Valachová, K., Šoltés, L.

Effects of biogenic transition metal ions Zn(II) and Mn(II) on hyaluronan degradation by action of ascorbate Plus Cu(II) ions.

(2021) New Steps in Chemical and Biochemical Physics. Pure and Applied Science, pp. 153-160.

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111288893&partnerID=40&md5=26e5b38722dc16847f84be11c9ed605e

 

2020

Novak I., Kleinova A., Matyasovsky J., Jurkovic P., Duchovic P., Valachova K., Soltes L. Investigation of Wood Surfaces Modification by Radio-Frequency Plasma. In: "Research Methodologies and Practical Applications of Chemistry" L. Pogliani, A. K. Haghi, N. Islam (eds), Apple Academic Press, New Jersey, USA 2020 pp. 269-280 ISBN: 9781771887847 Product Info

 

Valachova K., Svik K., Biro Cs., Soltes L. Skin wound healing with composite biomembranes loaded by tiopronin or captopril. J. Biotechnol. 310(2020)49-53 https://doi.org/10.1016/j.jbiotec.2020.02.001

 

Tamer M. T., Hassan M. A., Valachova K., Omer A. M., El-Shafeey M. E. A., Mohy Eldin M. S., Soltes L. Enhancement of wound healing by chitosan/hyaluronan polyelectrolyte membrane loaded with glutathione: in vitro and in vivo evaluations. J. Biotechnol. 310 (2020) 103-113 https://doi.org/10.1016/j.jbiotec.2020.02.002

 

Valachova K., Hafez E. E., Nagy M., Soltes L. Antioxidative properties of Punica granatum, Peganum harmala, Dianthus caryophyllus, and Vitis vinifera extracts against free radicals. In: "Green Chemistry and Biodiversity, Principles, Techniques, and Correlations" C. N. Aguilar, S. C. Ameta, A. K. Haghi (eds), Apple Academic Press, New Jersey, USA 2020 pp. 135-152 ISBN: 9781771887946 Product Info

 

Soltes L., Valachova K., Mach M., Juranek I..Composite membranes containing a smart-released cytoprotectant targeting the inflamed tissue and use thereof. European Patent Application EP20020280.2 (priority date 17/06/2020)

 

Valachova K., Mach M., Soltes L. Oxidative degradation of high-molar-mass hyaluronan: Effects of some indole derivatives to hyaluronan decay. Int. J. Mol. Sci. 20 (2020) art. no. 5609

 

2019

Valachova K., Juranek I., Rapta P., Valent I., Soltes L. On infusion of high-dose ascorbate in treating cancer: Is it time for N-acetylcysteine pretreatment to enhance susceptibility and to lower side effects? Medical Hypotheses 122 (2019) 8-9 Download

 

Valachova K. Topolska D., Nagy M., Juranek I., Soltes L. Antioxidative activity of Azadirachta indica, Ocimum tenuiflorum, and Withania somnifera. In: "Physical Chemistry for Chemists and Chemical Engineers. Multidisciplinary Research Perspectives" A. V. Vakhrushev, R. Haghi, J. V. de Julian-Ortiz (eds), Apple Academic Press, New Jersey, USA, (2019) pp. 75-93 ISBN: 9781771886550 Product Info

 

Valachova K., Tamer M. T., Veverka M., Soltes L. Preparation of two quercetin derivatives and evaluation of their antioxidative activity. Engineering Technology and Industrial Chemistry with Applications, R. Haghi, F. Torrens (eds), Apple Academic Press, Taylor & Francis Group, New Jersey, USA, 2019 pp. 189-208 ISBN: 9781771886376 Product Info

 

Valachova K., Mach M., Dubovicky M., Soltes L. The importance of ergothioneine synthesis in ancient-time by organisms living in oxygen free atmosphere. Medical Hypotheses 123(2019) 72-73 Download

 

Kura B., Bagchi A., Singal P., Barancik M., LeBaron T., Valachova K., Soltes L., Slezak J. Molecular hydrogen (H2): Potential in mitigating oxidative stress-induced cardiotoxicity. Canadian Journal of Physiology and Pharmacology 97(2019)287-292, doi: 10.1139/cjpp-2018-0604

 

 

* CURRICULUM   VITAE *

 

 

Education, Earned Degree

 

1968-73               Faculty of Chemical Technology, Slovak Technical University, Bratislava, Dipl. Ing. - 1973 macromolecular chemistry (Diploma Work/MS-Thesis: Investigation of interactions in ternary polymeric systems by GPC, pp. 52. Research adviser: Dr. Dusan Berek)

 

1973-77               Faculty of Chemical Technology, Slovak Technical University, Bratislava, PhD. - 1978 macromolecular chemistry (PhD Thesis: Polymolecularity of high molecular mass polystyrene prepared by heterogeneously initiated radical polymerization, pp. 119. Research adviser: Prof. Dr. Darina Mikulasova)

 

1993                    DSc. - analytical chemistry (Research Prof. Thesis: Liquid chromatographic separation  methods for the analysis of biological materials, pp. 128.)

 

Email:                  ladislav.soltes@savba.sk                            

         

                                      Who is L. Soltes (in slovak)

 

Research Training/Experience

 

since 1979            Bioanalytically Applied Liquid Chromatographic Separation Methods

since 2012            Laboratory of Bioorganic Chemistry of Drugs

 

HPLC methods for the determination of xenobiotics in body fluids.

HPLC and HPTLC methods for isolation, purification, and evidence of drug metabolites.

HPLC methods for the study of drug binding to proteins.

SEC (GPC)   methods for the determination of molar mass and the distribution of molar masses of polymers, both natural and synthetic.

 

Current Research Interests and Achievements

 

Development of rotational viscometric methods to characterize antioxidative and/or free-radical-scavenging properties of prospective drugs.

 

Publications/Citations

 

https://www.scopus.com/authid/detail.uri?authorId=7006074358

 

Memberships

 

ISHAS - International Society for Hyaluronan Sciences

 

Academic Honor

 

1990 & 2000        Award of the Slovak Academy of Sciences, Bratislava, Slovakia

 

2008                     Scientist of the year 2007, Slovakia
 

Status                  Married (with Nelly), two sons (Thomas 1974, George 1977)

 

Languages              Slovak, Czech, English, French, Hungarian, Russian