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* PROJECTS *
In vitro study of antioxidative/antiinflammatory effects of natural and synthetic compounds. In vivo assessment of medicinal effects of selected compounds in experiments of healing skin wounds. VEGA No.: 2/0008/23 principal investigator Valachova K.
* PUBLICATION LIST
(Years
2021–2024/2025) *
Publications in PDF (1997–present)
2024/2025 Valachova K., Hassan M., Soltes L. Hyaluronan: Sources, structure, features and applications. Molecules 29/3(2024)739. https://doi.org/10.3390/molecules29030739
Valachova K., Moura N.M.M., Soltes L. Redox properties of Mn(III)porphyrins in hyaluronan oxidative degradation: Single electron transfer mechanism. Chemistry-A European Journal, (2024) e202401028, 1-7. https://doi.org/10.1002/chem.202401028
Valachova K., Kura B., Slezak J., Mach M., Soltes L. Comparison of free radical scavenging activity of various sources of molecular hydrogen. In: "Molecular Hydrogen in Health and Disease", Slezak J., Kura B. (eds.) Springer Nature Switzerland AG (2024) pp. 385–400 ISBN: 978-3-031-47374-6 https://doi.org/10.1007/978-3-031-47375-3
Novak I., Popelka A., Asanidezhad A., Lehocky M., Chodak I., Sedliacik J., Matyasovsky J., Jurkovic P., Valachova K., Soltes L. Investigation of selected antibacterially modified micro/nano polymers using cold plasma. In: "Nanotechnology-Enhanced Solid Materials Design, Synthesis, Properties, Applications, and Perspectives" L. Pogliani, A. R. Abraham, A. K. Haghi, P. Ranjan (eds), Apple Academic Press, Palm Bay, FL, USA (2024) pp. 237-257 ISBN: 9781774912201 Product Info
Novak I., Popelka A.,, Chodak I., Sedliacik J., Kleinova A., Micusik M., Matyasovsky J., Jurkovic P., Valachova K., Soltes L. Cold plasma: An efficient tool for nanotechnological modification of polyester-based polymers. In: "Tailored Functional Materials for Clean and Sustainable Development" T. Tatrishvili, N. K. Rawat, A. R. Abraham, A. K. Haghi (eds.), Apple Academic Press, Palm Bay, FL, USA (2024) pp. 33–56 ISBN: 9781774913659 Product Info
Hassan M.E., Tamer M.T., Valachova K., Ragab A., Soltes L. Derivatization of hyaluronan to improve its anti-inflammatory and antioxidant properties: Practical and in silico studies. International Journal of Biological Macromolecules, submitted
Hassan M.E, Tamer M.T., Valachova K., Soltes L. An overview of hyaluronic acid: structure, sources, and applications. In: "Advances in Health and Diseases". Nova Science Publishers, USA, submitted.
Hassan M.E., Tamer M.T., Valachova K., Soltes L. Microencapsulation process: methods, properties and applications. Bioprocess and Biosystems Engineering, submitted.
2023 Valachova K., Svik K., Jurcik R., Ondruska L., Biro C., Soltes L.: Enhanced healing of skin wounds in ischemic rabbits using chitosan/hyaluronan/edaravone composite membranes: effects of laponite, carbon and silver-plated carbon nanofiber fillers. Chemical Papers 77(2023)1835–1841 https://doi.org/10.1007/s11696-022-02553-x
Liskova S., Cacanyiova S., Cebova M., Berenyiova A., Kluknavsky M., Micurova A., Valachova K., Soltes L., Bernatova I. Taxifolin reduces blood pressure via improvement of vascular function and mitigating the vascular inflammatory response in spontaneously hypertensive rats. International Journal of Molecular Sciences 24(2023)1261
Soltes L., Valachova K., Svik K., Padej I., Mach M. Biomedical method of evaluation of pro- and/or antioxidative properties of plant polyphenols and its use thereof. (Biomedicínska metóda hodnotenia pro- a/alebo antioxidačných vlastností rastlinných polyfenolov a jej použitie.) SK patent application, No. PP 50030-2023, May 10
2022 Valachova K., El Meligy M.A., Soltes L. Hyaluronic acid and chitosan-based electrospun wound dressings: problems and solutions. International Journal of Biological Macromolecules 206(2022)74-91
Valent I., Bednarova L., Schreiber I., Bujdak J., Valachova K., Soltes L. Reaction of N-acetylcysteine with Cu2+: Appearance of intermediates with high free radical scavenging activity: Implications for anti-/pro-oxidant properties of thiols. International Journal of Molecular Sciences 23(2022)6199 https://doi.org/10.3390/ijms23116199
El Meligy M.A., Valachova K., Juranek I., Tamer M.T., Soltes L. Preparation and physicochemical characterization of gelatin-aldehyde derivatives. Molecules 27(2022)7003
Valachova K., Svík K., Biro C., Mach M., Juranek I., Soltes L. Self-associating chitosan-hyaluronan carrier for a drug treating injured skin. In: "Advances in Health and Disease", chapter 5, volume 50, Lowell T. Duncan (ed.), Nova Science Publishers, Inc., USA (2022), pp. 91-114, ISBN: 978-1-68507-564-4
Valachova K., Soltes L. Investigation of the substance antioxidative profile by hyaluronan, Cu(II) and ascorbate. In: "Advances in Health and Diseases", chapter 2, volume 51, Lowell T. Duncan (ed.), Nova Science Publishers, Inc. (2022), pp. 61-98, ISBN978-1-68507-657-3
2021 Valachova K., Svík K., Biro Cs., Collins M. N., Jurcik R., Ondruska L., Soltes L. Impact of ergothioneine, hercynine and histidine on oxidative degradation of hyaluronan and wound healing. Polymers 13(2021)95-103
Valachova K., Soltes L. Versatile use of chitosan and hyaluronan in medicine. Molecules 26(2021)1195
Valachova K., Soltes L. Self-associating polymers chitosan and hyaluronan for constructing composite membranes as skin-wound dressings carrying therapeutics. Molecules 26(2021)2535
Hassan M. A., Tamer M. T., Valachova K., Omer A. M., El-Shafeey M., Mohy Eldin M. S., Soltes L. Antioxidant and antibacterial polyelectrolyte wound dressing based on chitosan/hyaluronan/phosphatidylcholine dihydroquercetin. International Journal of Biological Macromolecules 166(2021)18-31
Valachova K., Soltes L. Hyaluronan as a prominent biomolecule with numerous applications in medicine. Int. J. Molecular Sci. 22(2021)7077, https://doi.org/10.3390/ijms22137077
Valachova K., Rapta P., Moura N. M M., Batinic-Haberle I., Soltes L. Ortho isomeric Mn(III) N-alkyl- and alkoxyalkylpyridylporphyrins – enhancers of hyaluronan degradation induced by ascorbate and cupric ions. Int. J. Molecular Sci. 22(2021)8608; https://doi.org/10.3390/ijms22168608
Valachova K., Soltes L. Assessment the substance antioxidative profile by hyaluronan, Cu(II) and ascorbate. Pharmaceutics 13(2021)1815
Valachova K., Rapta P., Batinic-Haberle I., Soltes L. Manganese porphyrins as pro-oxidants in high-molar-mass hyaluronan oxidative degradation. In: "Green Chemistry and Green Engineering. Processing, Technologies, Properties, and Applications" Apple Academic Press, Palm Bay, FL, USA (2021) pp. 223-241 ISBN: 9781771889001 Product Info
Valachova K., Susanikova I., Topolska D., Bogi E., Soltes L. Effects of N-acetylcysteine, glutathione, and glutathione disulfide on NIH 3T3, VH10 and MCF-7 cells exposed to ascorbate and Cu(II) ions. In: "Green Chemistry and Sustainable Technology Biological, Pharmaceutical, and Macromolecular Systems" S. (eds), Apple Academic Press, Palm Bay, Florida, USA (2021) pp. 77-93 ISBN: 9781771888622 Product Info
Maronek M., Novak I., Michalec I., Matyasovsky J., Jurkovic P., Valachova K., Soltes L. Analysis of fumes arising during fabrication of hybrid adhesive-laser joints. In: "Chemistry and Chemical Engineering for Sustainable Development. Best Practices and Research Directions" Apple Academic Press, Palm Bay, FL, USA (2021) pp. 229-251 ISBN: 9781771888707 Product Info
Valachova K., Rychly J., Janigova I., Csomorova K.,Juranek I., Soltes L. Bucillamine as an efficient H atom donor protects high-molar-mass hyaluronan from oxidative degradation by effective scavenging of free radicals. In: "Current Advances in Chemistry and Biochemistry" Vol. 7, Hooghly, West Bengal, India: B P International, (2021) pp. 123-138 ISBN: 9789391215569 https://stm.bookpi.org/CACB-V7/article/view/1193
Book Chapters, electronic re-editions
Stankovská, M., Šoltés, L. Oxidative degradation of hyaluronan: Is melatonin an antioxidant or prooxidant? (2021) Monomers, Oligomers, Polymers, Composites, and Nanocomposites, pp. 59-67.
Valachová, K., Mendichi, R., Šoltés, L. Effect of L-glutathione on high-molar-mass hyaluronan degradation by oxidative system Cu(II) plus ascorbate. (2021) Monomers, Oligomers, Polymers, Composites, and Nanocomposites, pp. 101-111.
Rapta, P., Valachová, K., Zalibera, M., Šnirc, V., Šoltés, L. Hyaluronan degradation by reactive oxygen species: Scavenging effect of the hexahydropyridoindole stobadine and two of its derivatives. (2021) Monomers, Oligomers, Polymers, Composites, and Nanocomposites, pp. 113-126.
Hrabárová, E., Šoltés, L. Peroxynitrite: A potent endogenous pro-oxidant agent playing an important role in degradation of hyaluronan biopolymer. (2021) Monomers, Oligomers, Polymers, Composites, and Nanocomposites, pp. 127-138.
Mislovicová, D., Šoltés, L. Neoglycoproteins of mannan: Preparation, characterization, properties, and applications. (2021) Monomers, Oligomers, Polymers, Composites, and Nanocomposites, pp. 151-165.
Šoltés, L. Hyaluronan - a high-molar-mass messenger reporting on the status of synovial joints: Part II. Pathophysiological status. (2021) New Steps in Chemical and Biochemical Physics. Pure and Applied Science, pp. 137-152.
Valachová, K., Šoltés, L. Effects of biogenic transition metal ions Zn(II) and Mn(II) on hyaluronan degradation by action of ascorbate Plus Cu(II) ions. (2021) New Steps in Chemical and Biochemical Physics. Pure and Applied Science, pp. 153-160.
* CURRICULUM VITAE *
Education,
Earned Degree 1968-73 Faculty of Chemical Technology,
Slovak Technical University, Bratislava, Dipl. Ing. - 1973 macromolecular
chemistry (Diploma Work/MS-Thesis: Investigation of
interactions in ternary polymeric systems by GPC, pp. 52. Research adviser:
Dr. Dusan Berek) 1973-77 Faculty of Chemical Technology,
Slovak Technical University, Bratislava, PhD. - 1978 macromolecular chemistry
(PhD Thesis: Polymolecularity of high molecular mass
polystyrene prepared by heterogeneously initiated radical polymerization, pp.
119. Research adviser: Prof. Dr. Darina Mikulasova) 1993 DSc. - analytical
chemistry (Research Prof. Thesis: Liquid chromatographic
separation methods for the analysis of biological materials, pp. 128.)
Email: ladislav.soltes@savba.sk
Research
Training/Experience since 1979 Bioanalytically Applied Liquid Chromatographic Separation Methods since 2012 Laboratory of Bioorganic Chemistry of Drugs HPLC methods for the
determination of xenobiotics in body fluids. HPLC and HPTLC methods
for isolation, purification, and evidence of drug metabolites. HPLC methods for the
study of drug binding to proteins. SEC
(GPC) methods for the determination of
molar mass and the distribution of molar masses of polymers, both natural and synthetic.
Current Research
Interests and Achievements
Development of rotational viscometric methods to
characterize antioxidative and/or free-radical-scavenging properties of
prospective drugs.
Publications/Citations https://www.researchgate.net/scientific-contributions/Ladislav-Soltes-39060943 https://www.scopus.com/authid/detail.uri?authorId=7006074358 Memberships
ISHAS - International Society for Hyaluronan Sciences
Academic
Honor 1990 & 2000 Award of the Slovak Academy of Sciences, Bratislava, Slovakia
2008
Scientist of the year
2007, Slovakia
Status
Married
(with Nelly), two sons
(Thomas 1974, George 1977) Languages Slovak, Czech, English, French, Hungarian, Russian
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